Spravato | 333 Therapeutics Consulting Llc

Spravato Nasal Spray

By 333 Therapeutics Consulting LLC

What is Spravato Nasal Spray?

SPRAVATO® (esketamine) is a prescription nasal spray used to treat adults with treatment-resistant depression and depressive symptoms associated with major depressive disorder with suicidal thoughts or actions. It works differently from traditional antidepressants by targeting the brain’s NMDA receptors, offering a rapid reduction in depressive symptoms—sometimes within 24 hours—when used alone or alongside an oral antidepressant.

Treatment is administered under the supervision of a healthcare provider in certified medical settings due to potential side effects such as sedation, dissociation, and respiratory depression. Patients typically undergo an initial phase of twice-weekly dosing over four weeks, with progress evaluated to determine if continued treatment is necessary. Close monitoring and structured programs ensure both safety and effectiveness throughout the treatment process.

Frequently Asked Questions

Who can benefit from Spravato?

‍Spravato may benefit adults with treatment-resistant depression (when two or more antidepressants haven’t worked) or those experiencing major depressive disorder with suicidal thoughts or actions. A healthcare provider will determine if it’s an appropriate option based on your condition and history.

‍

‍How does Spravato work?

‍Spravato works differently from traditional antidepressants by targeting NMDA receptors in the brain, which are involved in mood regulation. While its exact mechanism isn’t fully understood, it is believed to help restore connections in the brain that affect emotional well-being.

‍

‍What happens during Spravato treatment?

‍Spravato is self-administered as a nasal spray under the supervision of a healthcare provider in a certified clinic. Patients are monitored for at least two hours after each session to ensure safety and manage any side effects.

How often do I need to take Spravato?

333 Treatment typically starts with twice-weekly sessions for the first four weeks. After that, your provider may adjust the frequency based on how well you respond.

How quickly does Spravato start working?

Some patients may notice improvement in depressive symptoms within 24 hours, though results can vary. Continued treatment over several weeks is usually needed for the full effect.

Are there any side effects?

Common side effects include dizziness, nausea, dissociation (feeling disconnected), and sleepiness. These usually occur shortly after treatment and go away the same day, but monitoring is required.

Can I drive after a Spravato session?

No, you should not drive or operate machinery until the next day after a restful sleep. You’ll need to arrange transportation to and from your appointments.

Is Spravato covered by insurance?

Coverage varies by provider and plan, but many patients may qualify for assistance programs that help reduce out-of-pocket costs. It’s best to check with your provider or insurance company for details.